发明名称 Peptide nucleic acid derivatives with good cell penetration and strong affinity for nucleic acid
摘要 The present invention provides a novel class of peptide nucleic acid derivatives, which show good cell penetration and strong binding affinity for nucleic acid.
申请公布号 US8859766(B2) 申请公布日期 2014.10.14
申请号 US201314133045 申请日期 2013.12.18
申请人 OliPass Corporation 发明人 Chung Shin;Kim Heui-Yeon;Park Hyun-Jin;Kim Mi-Ran;Lee Jong-Ook
分类号 C07D239/00;C07D239/70 主分类号 C07D239/00
代理机构 Heslin Rothenberg Farley & Mesiti P.C. 代理人 Heslin Rothenberg Farley & Mesiti P.C. ;Gonsalves, Esq. Andrew K.
主权项 1. A compound of Formula VII: wherein, R8 is hydrido, N-succinyl, or substituted or non-substituted alkyl radical; P1 is selected from hydrido, t-butoxycarbonyl, (9H-fluoren-9-yl)methoxy-carbonyl, substituted or non-substituted benzyloxycarbonyl, and substituted or non-substituted arylsulfonyl radical; P2 is selected from hydrido, t-butoxycarbonyl, (9H-fluoren-9-yl)methoxy-carbonyl, substituted or non-substituted benzyloxycarbonyl, substituted alkyloxycarbonyl, substituted or non-substituted alkyl, amidinyl, 1,3-bis(t-butoxy-carbonyl)amidinyl, 1,3-bis-(benzyl-oxycarbonyl)amidinyl radical; P3 is selected from hydrido, t-butoxycarbonyl, (9H-fluoren-9-yl)methoxy-carbonyl, and substituted or non-substituted benzyloxycarbonyl radical; P4 is selected from hydrido, and t-butoxycarbonyl radical; and, L2 is a linker represented by Formula V: wherein, Q1 and Qm are substituted or non-substituted methylene radical, and Qm is directly linked to the amino radical; Q2, Q3, . . . , and Qm-1 are independently selected from substituted or non-substituted methylene, oxygen, sulfur, and substituted or non-substituted amino radical; and, m is an integer from 2 to 15.
地址 Suwon KR
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