Compositions for eliciting an immune response

摘要

The invention is directed to the use of (i) a first antigen corresponding to a target antigen of interest, together with (ii) a second antigen, corresponding to a modified form of the target antigen, whose rate of intracellular proteolytic degradation is increased, enhanced or otherwise elevated relative to the first antigen, in compositions and methods for inducing both humoral and cellular immunity in an individual. The ability to provide compositions, which are capable of inducing both host-protective antibody and cell-mediated immune responses, facilitates the generation of immunogenic compositions capable of combating, inter alia, conditions that have long latency periods and, therefore, benefit from the dual approach of prophylaxis and therapy in one delivery.

主权项

1. A composition for eliciting a humoral and a cellular immune response against a target antigen, comprising a first antigen corresponding to the target antigen, or a polynucleotide from which the first antigen is expressible, together with a second antigen corresponding to the target antigen and including an intracellular degradation signal, wherein the intracellular degradation signal is fused or conjugated to said second antigen, and wherein the rate of intracellular proteolytic degradation of the second antigen is increased, enhanced or otherwise elevated relative to the first antigen, or a polynucleotide from which the second antigen is expressible.