Peptide analogs capable of enhancing stimulation of a glioma-specific CTL response

摘要

The invention provides a peptide derived from the interleukin-13 receptor α2, which serves as a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope. The invention can be used as a vaccine for glioma and can be formulated into compositions for medical or veterinary use. In addition, the invention provides the use of a peptide derived from the Eph family of tyrosine kinase receptors which can be also used as a vaccine for glioma and can be formulated into compositions for medical or veterinary use.

主权项

1. A method of vaccinating a patient against glioma, comprising introducing into the patient (i) a peptide comprising TLADFDPRFV (SEQ ID NO:6) and (ii) a peptide comprising ALPFGFILV (SEQ ID NO:3)under conditions sufficient for said patient to develop a cytoxic T-cell lymphocyte (CTL) response.