| 摘要 |
FIELD: medicine.SUBSTANCE: invention relates to biology and medicine and is aimed at the increase of efficiency of the tumour growth suppression with the application of recombinant human proteins, which bind with a receptor of cytokine TRAIL/Apo2L and trigger apoptotic death of tumour cells, without damaging normal cells. In particular the invention relates to a method of suppressing the tumour growth. The invention consists in the fact that the said recombinant proteins, binding with receptors of cytokine TRAIL/Apo2L, are applied in a combination with substances, which suppress resistance of the tumour cells to TRAIL proteins, and in addition to it cyclic peptide Cys-Arg-Gly-Asp-Lys-Gly-Pro-Asp-Cys is applied. It is supposed that the said peptide enhances the penetration of TRAIL from the vessels to the tumour cells.EFFECT: application of a combination of recombinant TRAIL proteins and substances, which increase the sensitivity of the tumour cells to them, in a combination with the said peptide in accordance with the claimed invention, makes it possible to increase efficiency of the tumour growth suppression.3 dwg, 3 ex |
