| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: in general formulaAstands for CRRor S; Astands for CRR, C(=O), O, S or S(=O); Rstands for C-alkyl, saturated or unsaturated, branched or non-branched, non-substituted, or monosubstituted, or polysubstituted; C-cycloalkyl or 5- or 6-membered heterocyclyl with the O-atom, each time saturated or unsaturated, non-substituted, or monosubstituted, or polysubstituted; C-aryl or C-heteroaryl with 1-3 heteroatoms, selected from N, O or S, each time non-substituted, or monosubstituted, or polysubstituted; through C-alkyl or C-heteroalkyl bound by the bridge bond C-cycloalkyl, each time saturated, non-substituted, and the alkyl or heteroalkyl chain each time can be branched or non-branched, saturated, non-substituted; or through C-alkyl, bound by the bridge bond aryl or heteroaryl, each time non-substituted, or monosubstituted, or polysubstituted, and the alkyl chain each time can be branched or non-branched, saturated or unsaturated, non-substituted, or monosubstituted, or polysubstituted; R, Rand Reach time independently on each other stand for H; F; Cl; Br; I; methyl; O-C-alkyl or NRR, and Rand Rtogether with the nitrogen atom that binds them form heterocyclyl, saturated, non-branched, non-substituted; R, R, R, R, R, R, Rand Reach time independently on each other stand for H; F; Cl; Br; I; OH or C-alkul; or Rand Ror Rand Rtogether with carbon atom(s), that bind(s) them form C-cycloalkyl, each time saturated or non-saturated, non-substituted, or monosubstituted, or polysubstituted; with respective remaining substituents R, R, R, R, R, R, Rand Rhaving the value given above; Rstands for C-cycloalkyl, saturated, non-substituted; C-aryl or 5- or 6-membered heteroaryl with heteroatom, selected from N and S, each time non-substituted or monosubstituted.EFFECT: invention relates to substituted nicotinamides of general formula (1), to a medication based on them and their application for treating KCNQ2/3-mediated diseases.13 cl, 3 tbl, 224 ex |
