Cannabinoid Receptor Binding Agents, Compositions and Methods

摘要

A composition comprising a cannabinoid receptor binding agent contained in a particle for the treatment of skin conditions. The particle may be a nanoparticle, such as nanocrystalline cellulose. The particle may further be modified with functional moieties. Drug delivery properties may be modified by coating the particles or using vesicles to deliver the cannabinoid receptor binding agent and particle. A substrate may be used to deliver the composition to the skin.

主权项

1. A composition and drug delivery vehicle, comprising:
a. a cannabinoid receptor binding agent present at about 1% to about 55% by weight of the composition; b. a polymeric nanoparticle containing the cannabinoid receptor binding agent wherein the polymeric nanoparticle at its largest dimension is smaller than 400 nanometers and greater than 0 nanometers, wherein the polymeric nanoparticle comprises a biodegradable polymer, wherein the polymeric nanoparticle is present at 75% or less and greater than 1% by weight of the composition, and wherein the biodegradable polymer is selected from the group consisting of polylactides, polyglycolides, poly(lactide-co-glycolide)s, polylactic acids, polyglycolic acids, poly(lactic acid-co-glycolic acid)s, copolymers of polylactides and poly(lactide-co-glycolide)s, poly(amino acids), polyacrylates, polyketals, collagen, chitin, chitosan, dextran, alginate, gelatin, albumin, ovalbumin, elastin, laminin, fibronectin, polymerized starches, chondroitin sulfate, polysucrose, hyaluronic acid, and heparin; and c. a vesicle for carrying the cannabinoid receptor binding agent and the polymeric nanoparticle.