| 摘要 |
This application discloses liquid compositions for administration to a patient comprising midazolam and a pharmaceutically acceptable carrier, wherein the pH of the composition is about 6 or higher and / or an advantageous carrier system is present, the composition comprises less than about 200mg/ml cyclodextrin, and at least about 50% of the midazolam is present in solution. Uses of these compositions are also disclosed. 5776964 1 (GHMatters) P92098.AU.1 JBECKER 17-Sep-14 Effect of pH on Proportion of Midazolam Present in the Open Ring Form Percentage of Midazolam Present in the Open Ring Form o "N. 2 5 3 33> 4 4.5 5 53> pH Figure 1 5776964 1 (GHMatters) P92098.AU.1 .JBECKER 17-So-14 |
