| 发明名称 |
VACCINE |
| 摘要 |
There is provided a NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position between amino acids 130 and 297 as compared with the equivalent position in SEQ ID the mutation preferably being located within a rim domain, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:1 and having reduced toxicity compared with the toxicity of SEQ ID NO:1. The polypeptide is useful to vaccinate a subject against infection by Clostridium perfringens. |
| 申请公布号 |
US2014302094(A1) |
申请公布日期 |
2014.10.09 |
| 申请号 |
US201214354117 |
申请日期 |
2012.10.24 |
| 申请人 |
university of Exeter |
发明人 |
Titball Richard W.;Fernandes Da Costa Sérgio Paulo;Naylor Claire;Basak Ajit |
| 分类号 |
C07K14/33 |
主分类号 |
C07K14/33 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position between amino acids 130 and 297 as compared with the equivalent position in SEQ ID NO:3, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:1 and having reduced toxicity compared with the toxicity of SEQ ID NO:1. |
| 地址 |
Exeter GB |
