发明名称 |
ANTISENSE ANTIVIRAL COMPOUND AND METHOD FOR TREATING INFLUENZA VIRAL INFECTION |
摘要 |
The present invention relates to antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Orthomyxoviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of influenza virus infection in a mammal. Exemplary antisense antiviral compounds are substantially uncharged, or partially positively charged, morpholino oligonucleotides having 1) a nuclease resistant backbone, 2) 12-40 nucleotide bases, and 3) a targeting sequence of at least 12 bases in length that hybridizes to a target region selected from the following: a) the 5′ or 3′ terminal 25 bases of the negative sense viral RNA segment of Influenzavirus A, Influenzavirus B and Influenzavirus C; b) the terminal 30 bases of the 5′ or 3′ terminus of the positive sense vcRNA; c) the 45 bases surrounding the AUG start codon of an influenza viral mRNA and; d) 50 bases surrounding the splice donor or acceptor sites of influenza mRNAs subject to alternative splicing. |
申请公布号 |
US2014303073(A1) |
申请公布日期 |
2014.10.09 |
申请号 |
US201414251124 |
申请日期 |
2014.04.11 |
申请人 |
Sarepta Therapeutics, Inc. |
发明人 |
Iversen Patrick L. |
分类号 |
C07F9/6561;A61K31/5377;A61K38/08;A61K31/545;A61K31/7056;C12N15/113;C07K7/08;A61K38/10;A61K31/165;C07K7/06;A61K31/43 |
主分类号 |
C07F9/6561 |
代理机构 |
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代理人 |
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主权项 |
1. An oligonucleotide consisting of the following structure: |
地址 |
Corvallis OR US |