PREDICTING PROGNOSIS IN CLASSIC HODGKIN LYMPHOMA

摘要

Predictor genes and methods for determining prognosis in classic Hodgkin's lymphoma (cHL) are described herein. Expression levels of predictor genes ALDH1A1, APOL6, B2M, CD300A, CD68, CXCL11, GLUL, HLA-A, HLA-C, IFNG, IL15RA, IRF1, LMO2, LYZ, PRF1, RAPGEF2, RNF144B, STAT1, TNFSF10, WDR83, CCL17, COL6A1, and PDGFRA are used to derive a score within a prognostic model. Measurement of expression levels may involve counting RNA molecules using digital profiling, such as the NanoString™ platform. The score is compared to a threshold indicative of outcome. Associated kits, commercial packages, panels of biomarkers, and uses are also provided.

主权项

1. A method for predicting prognosis in a subject having cHL comprising:
measuring, in a sample from tumour tissue from the subject, expression levels of predictor genes comprising ALDH1A1, APOL6, B2M, CD300A, CD68, CXCL11, GLUL, HLA-A, HLA-C, IFNG, IL15RA, IRF1, LMO2, LYZ, PRF1, RAPGEF2, RNF144B, STAT1, TNFSF10, WDR83, CCL17, COL6A1, and PDGFRA; using said expression levels to derive a score; providing a reference model comprising information correlating said score with prognosis, said model comprising a threshold beyond which poor prognosis is predicted; comparing the score to the threshold; and predicting poor prognosis in the subject if the score is beyond the threshold.