DIAGNOSIS OF PULMONARY AND/OR CARDIOVASCULAR DISEASE

摘要

Described are methods and kits for determining the likelihood of the presence of cardiovascular disease (CVD) or pulmonary disease (PD) in a subject using ST2/Interleukin 1 Receptor Like 1 (IL1RL1) and/or Interleukin 33 (IL-33), and a biomarker for CVD, e.g., a natriuretic peptide, e.g., brain natriuretic peptide (BNP), prohormone BNP (proBNP), N-Terminal proBNP (NT-proBNP), atrial natriuretic peptide (ANP), proANP, or NT-proANP.

主权项

1. A kit for determining the likelihood of the presence of cardiovascular disease (CVD) or pulmonary disease (PD) in a subject, the kit comprising (i) one or both of a binding composition that specifically binds to IL-33 and a binding composition that specifically binds to ST2, (ii) a binding composition that specifically binds to a biomarker for CVD, and (iii) instructions for use in a method of determining the likelihood of the presence of CVD or PD in a subject, the method comprising:
determining a level of one or both of IL-33 and ST2 in a sample from a subject; determining a level of a biomarker for CVD in the sample; and comparing the level of IL-33 or ST-2, and the level of the CVD biomarker, in the sample to preselected corresponding reference levels; wherein the levels in the sample as compared to the reference levels is correlated with the likelihood of the presence of CVD or PD.