VEGF-BINDING PROTEIN FOR BLOCKADE OF ANGIOGENESIS

摘要

Provided are chimeric VEGF-binding proteins and nucleic acids (e.g., a vector) encoding chimeric VEGF-binding proteins, methods and host cells for producing these proteins and nucleic acids, and pharmaceutical compositions containing these proteins and nucleic acids. Also provided are methods of treating an angiogenic disease or disorder that include administering at least one of the chimeric VEGF-binding proteins or at least one of the nucleic acids (e.g., a vector) encoding a chimeric VEGF-bind ing protein.

主权项

1. A chimeric VEGF-binding protein comprising a first portion, the first portion consisting of amino acids 129-231 of the flt-1 tyrosine kinase receptor (SEQ ID NO:1), and a second portion comprising an Fc region of immunoglobulin G1.