发明名称 |
SITE-SPECIFIC ANTIBODY-DRUG CONJUGATION THROUGH GLYCOENGINEERING |
摘要 |
The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site- specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypetpide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided. |
申请公布号 |
CA2902530(A1) |
申请公布日期 |
2014.10.09 |
申请号 |
CA20142902530 |
申请日期 |
2014.03.10 |
申请人 |
GENZYME CORPORATION |
发明人 |
PAN, CLARK;ZHOU, QUN;STEFANO, JAMES;DHAL, PRADEEP;CHEN, BO;GIANOLIO, DIEGO;MILLER, ROBERT;QIU, HUAWEI |
分类号 |
A61K39/00;C07K16/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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