PHARMACEUTICAL COMPOSITIONS AND METHODS USEFUL FOR MODULATING ANGIOGENESIS, INHIBITING METASTASIS AND TUMOR FIBROSIS, AND ASSESSING THE MALIGNANCY OF COLON CANCER TUMORS

摘要

Methods and compositions suitable for modulating angiogenesis in a mammalian tissue are provided. Further provided are methods suitable for inhibiting metastasis and fibrosis in a mammalian tissue and for assessing the malignancy of colon cancer tumors.

主权项

1. A method of determining that a colon tumor is metastatic, comprising:
(a) obtaining a first sample of colon tumor tissue; (b) obtaining a second sample of colon tumor tissue, which is non-metastatic; and (c) determining that a tissue level and/or an activity level of a polypeptide having an amino acid sequence set forth in SEQ ID NO: 2 is higher in the first colon tumor tissue sample than in the second colon tumor tissue sample; thereby determining that the tumor from which the first sample was derived is metastatic.