METHOD FOR PRODUCING REPROGRAMMED DERIVATIVE NEURONAL STEM CELL FROM NON-NEURONAL CELL BY USING HMGA2

摘要

The present invention relates to a method for producing a reprogrammed derivative neuronal stem cell from a differentiated cell. A method for producing a derivative neuronal stem cell according to the present invention can produce a derivative neuronal stem cell from a non-neuronal cell only by using two derivative factors of SOX2 and HMGA2, and so is more effective compared to the conventional method using 4 derivative factors or 5 derivative factors. Also the method considerably enhances the derivation efficiency and proliferation capability compared to the method using only one derivative fact of SOX2, thus enlarging the applicability of the stem cell to treating diseases.