DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF

摘要

PROBLEM TO BE SOLVED: To provide: engineered multivalent and multispecific binding proteins; methods of making them; and their method for the diagnosis, prevention and/or treatment of acute and chronic inflammatory diseases, cancer, and other diseases.SOLUTION: A binding protein comprises first and second polypeptide chains. The polypeptide chains each independently comprises VD1-(X1)n-VD2-C-(X2)n (VD1 is a first variable domain; VD2 is a second variable domain; C is a constant domain; X1 is a linker; X2 is an Fc region; and n is 0 or 1). In the binding protein, VD1 domains of first and second polypeptide chains form a first functional target-binding region, and VD2 domains of first and second polypeptide chains form a second functional target-binding region.