| 摘要 |
<p>The present invention relates to a ghost vaccine composition containing ghost salmonella mutants as active ingredients for simultaneously preventing salmonellosis and colibacillosis. The ghost salmonella mutant according to the present invention is a ghost salmonella mutant expressing at least one adhesin selected from the group comprising F4ab (K88ab), F4ac (K88ac), F5 (K99), F6 (FasA), and F41. By combining one or more ghost salmonella mutants, mucosal and systemic immune responses are induced in the mucous membrane of a sow, and the ghosting process is strictly controlled, thereby being very effective in simultaneously preventing salmonellosis and colibacillosis in piglets. Therefore, the ghost vaccine containing the ghost salmonella mutants according to the present invention can enhance immunity of the piglets by being inoculated to the sow, and oral and intranasal inoculation are practicable.</p> |
