Antibodies against human tweak and uses thereof

摘要

An antibody binding to TWEAK comprising as heavy chain variable domain a CDR3H selected from the group consisting of SEQ ID NO: 8, 16 or 24.

主权项

1. An isolated nucleic acid that encodes an antibody that binds to human TWEAK, comprising:
a) a variable heavy chain comprising CDR1H with the amino acid sequence of SEQ ID NO:22, CDR2H with the amino acid sequence of SEQ ID NO:23, CDR3H with the amino acid sequence of SEQ ID NO:24, and a variable light chain comprising CDR1L with the amino acid sequence of SEQ ID NO:18, CDR2L with the amino acid sequence of SEQ ID NO:19, and CDR3L with the amino acid sequence of SEQ ID NO:20; or b) a variable heavy chain comprising CDR1H with the amino acid sequence of SEQ ID NO:22, CDR2H with the amino acid sequence of SEQ ID NO:74, CDR3H with the amino acid sequence of SEQ ID NO:24, and a variable light chain comprising CDR1L with the amino acid sequence of SEQ ID NO:18, CDR1L with the amino acid sequence of SEQ ID NO:19, and CDR3L of SEQ ID NO:20; or c) a variable heavy chain comprising CDR1H with the amino acid sequence of SEQ ID NO:22, CDR2H with the amino acid sequence of SEQ ID NO:75, CDR3H with the amino acid sequence of SEQ ID NO:24, and a variable light chain comprising CDR1L with the amino acid sequence of SEQ ID NO:18, CDR1L with the amino acid sequence of SEQ ID NO:19, and CDR3L with the amino acid sequence of SEQ ID NO:20.