<i>Vibrio cholerae</i> O139 conjugate vaccines

摘要

The disclosure pertains to conjugates of the capsular polysaccharide of Vibrio cholerae O139, or a structurally and/or immunologically related oligo- or poly-saccharide, and a carrier. These conjugates are useful as pharmaceutical compositions and/or vaccines to induce serum antibodies which have bactericidal (vibriocidal) activity against V. cholerae, in particular V. cholerae O139, and are useful to prevent, treat and/or reduce the severity of disease caused by V. cholerae infection, such as cholera. The present disclosure also relates to diagnostic tests for V. cholerae infection, and/or cholera caused by V. cholerae infection, using one or more of the oligo- or poly-saccharide-carrier conjugates or antibodies described above.

主权项

1. A conjugate molecule, consisting essentially of the capsular polysaccharide of Vibrio cholera O139, hydroxyl coupled to a adipic acid hydrazide-recombinant diphtheria toxin mutant CRMH21G carrier protein, wherein the polysaccharide to protein ratio is about 0.90 and the conjugated molecule elicits serum antibodies vibriocidal to Vibrio cholera O139 and diphtheria.