发明名称 |
METABOLICALLY ENGINEERED BACTERIAL STRAINS HAVING NON-FUNCTIONAL ENDOGENOUS GLUCONATE TRANSPORTERS |
摘要 |
The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the production of ASA intermediates in bacterial cells by enhancing the availability of gluconate resulting from the inactivation of endogenous gluconate transporter genes. |
申请公布号 |
CA2526595(C) |
申请公布日期 |
2014.10.07 |
申请号 |
CA20042526595 |
申请日期 |
2004.05.10 |
申请人 |
GENENCOR INTERNATIONAL, INC. |
发明人 |
DODGE, TIMOTHY C.;VALLE, FERNANDO;KUMAR, MANOJ;RASHID, M. HARUNUR |
分类号 |
C12N15/31;C07K14/24;C12N;C12N1/20;C12N1/21;C12N9/10;C12P7/40;C12P7/58;C12P7/60;C12P17/04 |
主分类号 |
C12N15/31 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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