发明名称 |
MUTANT CYAA POLYPEPTIDES AND POLYPEPTIDE DERIVATIVES SUITABLE FOR THE DELIVERY OF IMMUNOGENIC MOLECULES INTO A CELL |
摘要 |
The invention relates to mutant CyaA/E570Q+K860 polypeptides suitable for use as proteinaceous vectors for delivering one or more molecules of interest into a cell, in particular into a cell expressing the CD11b receptor. The invention further relates to polypeptide derivatives suitable for eliciting an immune response in a host. The invention is more particularly directed to polypeptides derived from an adenylate cyclase protein (CyaA) either under the form of a toxin or of a toxoid, which are mutant polypeptides. Said mutant polypeptides are capable of retaining the binding activity of native CyaA to a target cell and preferably of also retaining the translocating activity of native CyaA through its N-terminal domain into target cells and furthermore have a pore-forming activity which is reduced or suppressed as compared to that of the native CyaA toxin. |
申请公布号 |
PT2233569(E) |
申请公布日期 |
2014.10.06 |
申请号 |
PT20090155929T |
申请日期 |
2009.03.23 |
申请人 |
INSTITUT PASTEUR;INSTITUTE OF MICROBIOLOGY OF THE ASCR, V.V.I.;INSTITUTE OF PHYSIOLOGY OF THE ASCR, V.V.I. |
发明人 |
CLAUDE LECLERC;PETER SEBO;ADRIANA OSICKOVA;CATHERINE FAYOLLE;JIRI MASIN;JAN KRUSEK;RADIM OSICKA;MAREK BASLER |
分类号 |
C12N9/88 |
主分类号 |
C12N9/88 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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