| 摘要 |
A method of treating an Hepatitis C Virus infection in a patient, comprising providing a therapeutically effective amount, to a patient in need thereof, of a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: G1 is a group of the formula or where n is 0, 1, 2, 3, or 4 and Het is a 5- or 6-membered heteroaryl group containing 1 to 4 heteroatoms independently chosen from N, O, and S, which Het is optionally substituted.; |
| 主权项 |
1. A method of treating an Hepatitis C Virus infection in a patient, comprising providing a therapeutically effective amount, to a patient in need thereof, of a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein: G1 is a group of the formulawhere n is 0, 1, 2, 3, or 4 and Het is a 5- or 6-membered heteroaryl group containing 1 to 4 heteroatoms independently chosen from N, O, and S, which Het is optionally substituted;
Ar1 is a 6,6-fused or 6,5 bicyclic aromatic ring system containing only carbon ring atoms or containing 1, 2, or 3 nitrogen ring atoms with remaining atoms being carbon, which Ar1 is optionally substituted, Ar2 is phenyl, a 6-membered heteroaryl ring containing 1 or 2 nitrogen ring atoms, or a 6,5 bicyclic aromatic ring system containing 1, 2, or 3, nitrogen atoms, with remaining atoms being carbon, which Ar2 is optionally substituted; R is a group of the formula —NH(C═O)— or —(O═C)NH—; R3 is hydrogen or C1-C6alkyl; R3 is taken together with an Ar2 substituent to form a 5- or 6-membered unsaturated or aromatic R3/Ar2 ring having 0, 1, or 2 heteroatoms independently chosen from N, O, and S, which R3/Ar2 ring is optionally substituted; R4 is hydrogen or C1-C6alkyl; R5 is amino, —NHOH, or optionally substituted mono- or di-alkylamino, and R6 is hydrogen or hydroxyl; or R5 and R6 are taken together to form a 5 or 6-membered heterocyclic ring, which is unsaturated or aromatic and which contains 0, 1, or 2 additional heteroatoms chosen from N, S, and O, which 5 or 6-membered heterocyclic ring is optionally substituted. |
