| 发明名称 |
Crystalline Forms of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride |
| 摘要 |
A hitherto unknown crystalline form of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride, pharmaceutical compositions containing the new crystalline form, methods of producing the new crystalline form, and a related method of use including treatment of, e.g., pain and/or urinary incontinence. |
| 申请公布号 |
US2014296346(A1) |
申请公布日期 |
2014.10.02 |
| 申请号 |
US201414304313 |
申请日期 |
2014.06.13 |
| 申请人 |
GRUENENTHAL GmbH |
发明人 |
FISCHER Andreas;BUSCHMANN Helmut;GRUSS Michael;LISCHKE Dagmar |
| 分类号 |
C07C213/10;C07C215/54 |
主分类号 |
C07C213/10 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A process for producing a (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride of crystalline Form A, said process comprising:
dissolving a (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride of crystalline Form B in acetone, acetonitrile or isopropanol to form a solution; leaving the solution to crystallize and isolating crystals of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride of crystalline Form A. |
| 地址 |
Aachen DE |
