MULTIFUNCTIONAL QUINOLINE DERIVATIVES AS ANTI-NEURODEGENERATIVE AGENTS

摘要

Novel quinoline derivatives are disclosed. Also disclosed are synthesis and use thereof for treating neurodegenerative diseases.

主权项

1. A compound of Formula (I) or a pharmaceutically acceptable salt, a solvate or hydrate, a prodrug, or a metabolite thereof:wherein
R1 is hydrogen, (C1-C8)alkyl, (C1-C8)alkylene(C3-C8)cycloalkyl, (C1-C8)haloalkyl, or (C1-C8)alkylene(C6-C20)aryl; R2 is hydrogen or halogen; R3is hydrogen, halogen, (C1-C8)alkyl, or (C1-C8)alkoxy; R4 is hydrogen, halogen, (C1-C8)alkyl, (C1-C8)alkoxy, or (C1-C8)haloalkyl; R5 is hydrogen or (C1-C20)alkanol; R6 is hydrogen; and R7 is hydrogen, (C1-C20)alkanol, (C1-C8)alkylene (C3-C8)heterocyclyl(C1-C20)alkanol, (C1-C8)alkylene (C3-C8)heterocyclyl(C1-C20)alkyl, (C1-C8)alkylene(C1-C6)alkylamino(C1-C6)alkynyl, (C1-C8)alkyleneamino(C1-C20)alkanol, or (C1-C8)alkyleneamino(C1-C20)alkanol(C1-C8)alkylene substituted (C3-C20)heteroaryl.