Analyte Detection Using Magnetic Hall Effect

摘要

Determining a presence of a target analyte in a fluid sample includes mixing multiple magnetic particles with the fluid sample, in which the magnetic particles are each bound to one or more binding moieties that specifically bind to the target analyte, flowing the fluid sample containing the magnetic particles through a fluidic channel, exposing the fluid sample in the fluidic channel to a magnetic field, measuring a signal from a Hall effect sensor while the fluid sample flows through the fluidic channel, and determining whether the target analyte is present in the fluid sample when the measured signal is in a first range of values.

主权项

1. A target analyte detection device comprising:
a substrate comprising a Hall effect sensor, a fluidic channel arranged on a surface of the substrate and extending over a detection area of the Hall effect sensor, a magnet arranged to generate a magnetic field in the fluidic channel; and control electronics coupled to the Hall effect sensor, wherein the control electronics are configured to cause the device to:
detect a signal from the Hall effect sensor; anddetermine a presence of a target analyte in the fluidic channel based on the signal.