发明名称 |
CGRP RECEPTOR AGONIST FOR HIV TREATMENT OR PREVENTION |
摘要 |
A first object of the invention is CGRP or an agonist of the CGRP receptor for use in the prevention of an HIV infection in a human subject. A second object of the invention is a method for selecting an active compound for the prevention of an HIV infection in a human subject, comprising the steps of: a)contacting Langerhans cells with a candidate compound; b) in vitroinfecting of Langerhans cells from step a) by at least one HIV variant, c) measuring of at least one of the following parameters: HIV content, adhesive potential of Langerhans cells, in particular to TCs, secretion of anti-HIV chemokines by Langerhans cells. A third object of the invention is therefore a composition comprising CGRP or agonist of the CGRP receptor for use in the prevention of an HIV infection in a human subject. A fourthobject of the invention is a method for the in vitro diagnosis of an HIV infection in a human subject, characterized in that it comprises determining the level of CGRP from a biological sample from said subject. A fifth object of the invention is a method for assaying the efficiency of HAART in the treatment of HIV infection in a subject, characterized in that it comprises determining the level of CGRP from a biological sample from said subject. |
申请公布号 |
WO2014154891(A1) |
申请公布日期 |
2014.10.02 |
申请号 |
WO2014EP56356 |
申请日期 |
2014.03.28 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);UNIVERSITE PARIS DESCARTES |
发明人 |
BOMSEL, MORGANE;GANOR, YONATAN |
分类号 |
A61K38/08;A61K38/16;A61P31/18;G01N33/68 |
主分类号 |
A61K38/08 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|