| 发明名称 | Method for production of directly compressible ibuprofen formulations | ||
| 摘要 | A directly tabletable ibuprofen formulation comprising a) 50-99% by weight of crystalline ibuprofen, b) 1-15% by weight of a finely divided excipient with a surface area of at least 100 m2/g, and c) 0-40% by weight of further excipients, with the proviso that the total amount of components a) to c) corresponds to 100% by weight, where at least 50% of the surface of the ibuprofen crystals are covered with the finely divided excipient. | ||
| 申请公布号 | US8846085(B2) | 申请公布日期 | 2014.09.30 |
| 申请号 | US200612089416 | 申请日期 | 2006.10.05 |
| 申请人 | BASF SE | 发明人 | Meyer-Boehm Kathrin;Kolter Karl;Quadir Anisul |
| 分类号 | A61K9/20;A61K9/22;A61K9/26;C07C63/04;A61K31/19;A61K31/192 | 主分类号 | A61K9/20 |
| 代理机构 | Drinker Biddle & Reath LLP | 代理人 | Drinker Biddle & Reath LLP |
| 主权项 | 1. A process for producing a directly tabletable ibuprofen formulation comprising a. 50-99% by weight of crystalline ibuprofen; b. 1-15% by weight of a finely divided excipient with a surface area of at least 100 m2/g; and c. 0-40% by weight of further excipients;wherein the total amount of a), b), and c) corresponds to 100% by weight and at least 50% of the surface of the ibuprofen crystals is covered with said finely divided excipient comprising mixing ibuprofen or a salt thereof with finely divided silica for at least 1 hour and then mixing in the remaining additives to form a mixture. | ||
| 地址 | DE | ||