Collagen-binding synthetic peptidoglycans, preparation, and methods of use

摘要

This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding synthetic peptidoglycan where the collagen-binding synthetic peptidoglycan can be aberrant or can have amino acid homology with a portion of the amino acid sequence of a protein or a proteoglycan that regulates collagen fibrillogenesis. The invention also relates to kits, compounds, compositions, and engineered graft constructs comprising such collagen-binding synthetic peptidoglycans or engineered collagen matrices and methods for their preparation and use.

主权项

1. A compound of formula (PnL)χG wherein n is 1 to 5;
X is 1 to 10; P is a synthetic peptide of up to about 40 amino acids comprising the amino acid sequence RRANAALKAGELYKSILYGC (SEQ ID NO: 1) wherein the amino acid sequence comprises a collagen-binding domain; L is a linker which links “P” and “G” in said formula; and G is a glycan, wherein P is linked to G via the linker.