| 发明名称 | Methods of improving stem cell homing and engraftment | ||
| 摘要 | A method of enhancing cell engraftment potential is provided. The method comprising ex-vivo or in-vitro subjecting a population of cells to an amount of nicotinamide for a period of time sufficient to effect the population of cells, thereby enhancing cell engraftment potential. | ||
| 申请公布号 | US8846393(B2) | 申请公布日期 | 2014.09.30 |
| 申请号 | US200612085406 | 申请日期 | 2006.11.29 |
| 申请人 | Gamida-Cell Ltd. | 发明人 | Peled Tony |
| 分类号 | C12N5/02;C12N5/07;C12N5/071;C12N5/0789;A61K35/12 | 主分类号 | C12N5/02 |
| 代理机构 | Cooley LLP | 代理人 | Elrifi Ivor R.;Pavao Matthew;Cooley LLP |
| 主权项 | 1. A method of enhancing cell homing and engraftment potential, the method comprising ex-vivo or in vitro culturing a population of isolated CD34+ hematopoietic stem cells in the presence of 1 to 10 mM nicotinamide for a period of time of 5-30 hours, wherein said period of time is insufficient for proliferation of said isolated CD34+ hematopoietic stem cells, and wherein said culturing results in down-regulation of CD26 expression as compared to isolated CD34+ hematopoietic stem cells cultured in the absence of nicotinamide. | ||
| 地址 | Jerusalem IL | ||