发明名称 |
sVEGFR-2 and its role in lymphangiogenesis modulation |
摘要 |
Disclosed herein are nucleic acid molecules comprising a nucleotide sequence of sVEGF-2, proteins encoded by those sequences and antibodies that bind to the protein. Also disclosed are methods for inhibiting or enhancing expression or activity of sVEGFR-2 and methods for inhibiting graft rejection, particularly cornea graph rejection. Also described are methods for inhibiting lymphangiogenesis and lymphatic endothelial cell proliferation by administering an effective amount of sVEGFR-2 and methods for treating lymphedema by inhibiting the activity of sVEGFR-2. |
申请公布号 |
US8846386(B2) |
申请公布日期 |
2014.09.30 |
申请号 |
US200812338728 |
申请日期 |
2008.12.18 |
申请人 |
University of Kentucky Research Foundation |
发明人 |
Ambati Jayakrishna;Albuquerque Rumulo J. C. |
分类号 |
C12N15/63;C12N15/85;C07K14/71;G01N33/566;G01N33/574;A61K38/00 |
主分类号 |
C12N15/63 |
代理机构 |
Crowell & Moring LLP |
代理人 |
Crowell & Moring LLP |
主权项 |
1. A vector comprising an isolated nucleic acid molecule consisting of (i) a nucleotide sequence of SEQ ID NO:4 or (ii) a degenerate sequence of SEQ ID NO:4, wherein said degenerate sequence encodes a polypeptide consisting of the amino acid sequence set forth in SEQ ID NO:5, wherein the nucleic acid molecule is in operable linkage with a promoter. |
地址 |
Lexington KY US |