Multipole ion guide ion trap mass spectrometry with MS/MSⁿanalysis

摘要

A Time-Of-Flight mass analyzer includes a multipole ion guide located in the ion flight path between the ion source and the flight tube of the Time-Of-Flight mass analyzer. The multipole ion guide can be positioned in the ion path between the ion source and the ion pulsing region of the TOF mass analyzer. The multipole ion guide electronics and the ion guide entrance and exit electrostatic lenses are configured to enable trapping or passing through of ions delivered from an atmospheric pressure ion source. The multipole ion guide can be used for ion transmission, trapping and fragmentation, and can reside in one vacuum pumping stage or can extend continuously into more than one vacuum pumping stage.

主权项

1. An apparatus for analyzing chemical species comprising:
(a) at least two vacuum stages, each of said vacuum stages having means for pumping away gas to produce a partial vacuum, (b) an ion source for producing ions and delivering said ions into a first of said vacuum stages, (c) at least one multipole ion guide comprising a plurality of parallel poles and an internal volume defined therein by said plurality of parallel poles, said at least one multipole ion guide being located in at least one of said vacuum stages, (d) a means for applying electrical voltages to said plurality of parallel poles of said at least one multipole ion guide, said electrical voltages having AC and DC components, (e) means for moving said ions into a at least one multipole ion guide, (f) electrode elements located at an entrance and exit ends of said at least one multipole ion guide, (g) means for applying electrical voltages to said electrode elements, (h) a Time-of-Flight mass analyzer and detector located in at least one of said vacuum stages, (i) a means for controlling said electrical voltages applied to said plurality of parallel poles of said at least one multipole ion guide and a means for controlling said electrical voltages applied to said electrode elements such that selected m/z values of said ions produced by said ion source are fragmented in said internal volume of said at least one multipole ion guide and at least a portion of said fragment ions are directed to said Time-of-Flight mass analyzer and detector for mass analysis.