| 发明名称 | Double-stranded RNA molecules with stability in mammalian body fluid, preparation and application thereof | ||
| 摘要 | The present invention discloses preparation and application of double-stranded RNA molecules stable in mammalian body fluids. The mammalian-body-fluid-stable RNA molecules disclosed in the present invention are comprised of only unmodified nucleotides. For the first time, the present invention discloses the applications of mammalian-body-fluid-stable RNA molecules for immunotherapy and siRNA drug development. | ||
| 申请公布号 | US8846895(B2) | 申请公布日期 | 2014.09.30 |
| 申请号 | US201113582936 | 申请日期 | 2011.03.29 |
| 申请人 | Biomics Biotechnologies Co. Ltd. | 发明人 | Du Quan;Liang Zicai |
| 分类号 | C07H21/04;C07H21/02;C12Q1/68;A61K48/00 | 主分类号 | C07H21/04 |
| 代理机构 | Fox Rothschild LLP | 代理人 | Fox Rothschild LLP ;Hao Jianming Jimmy |
| 主权项 | 1. An isolated, synthesized small interfering RNA molecule, wherein the RNA molecule has at least one of the following sequence properties: the content of CA/UG and/or UG/CA sequence is not greater than 3%; and the content of the combination of UA/UA and (CA/UG and/or UG/CA) sequence is not greater than 10%. | ||
| 地址 | CN | ||