Phosphate-containing nanoparticle delivery vehicle

摘要

A phosphate-containing nanoparticle delivery vehicle includes nanoparticle, an active ingredient, and a phosphodiester moiety connecting the nanoparticle and the active ingredient and forms a prodrug. The nanoparticle delivery vehicle achieves the function of increasing hydrophilicity of the active ingredient and specificity against tumor cells. Advantages of the nanoparticle material include biocompatibility, magnetism and/or controllable drug release.

主权项

1. A phosphate-containing nanoparticle delivery vehicle of the formula:wherein NP is a nanoparticle, and the nanoparticle comprises a core domain and contains more than one metallic element, semiconductor element or an organic condensed matter or the nanoparticle is made of a member selected from the group consisting of silver, cobalt, nickel, titanium dioxide, zinc oxide, tin dioxide, copper, aluminum, cadmium selenide, silicon dioxide and diamond, wherein the metallic element is a member selected from the group consisting of silver, aluminum, platinum, palladium, copper, cobalt, iron, nickel, manganese, gadolinium, molybdenum;
R1 is paclitaxel; R2 is OH; each of X, Y is O; and Z is O.