Highly penetrating compositions and methods for treating pathogen-induced disordered tissues

摘要

Compositions and methods for treating disordered tissues, such as caused by pathogens and/or by toxins. The treatment compositions include an anti-infective active agent, a liquid carrier, and benzocaine in an amount so that the treatment composition penetrates more quickly into disordered tissue compared to the treatment composition in the absence of the benzocaine. In addition, the benzocaine can increase residence time of the anti-infective active in the treatment area. The preferred anti-infective active agent can be an organohalide, such as a quaternary ammonium halide compound, an example of which is benzalkonium chloride. The treatment compositions and methods may employ the use of an applicator adapted for use in promoting penetration of the treatment composition and/or agitation of the disordered tissue to further enhance penetration.

主权项

1. A method for the treatment of disordered tissue caused by a herpes virus by administering a treatment composition in a subject in need thereof comprising:
at least one benzalkonium chloride compoundwhere R═X8H17 to C18H37;
a liquid carrier comprising a tissue penetrating component for penetrating disordered tissue in a rapid manner without rapidly diffusing beyond the skin; and benzocaine present in an amount ranging from 3.5% to about 20% so that the treatment composition is more effective in treating disordered tissue caused by a herpes virus compared to the treatment composition in the absence of benzocaine.