| 主权项 |
1. A compound, or a pharmaceutically acceptable salt or solvate thereof, having a formula (I): wherein, Ar indicates (1) a C6 to C14 aromatic hydrocarbon group, (2) a 5 to 8-membered aromatic heterocyclic group having 1 to 4 hetero atoms selected from the group consisting of a nitrogen atom, sulfur atom, and oxygen atom, in place of a carbon atom, or (3) a bicyclic or tricyclic aromatic group formed by condensation of the above aromatic heterocyclic group and a C6 to C14 aromatic hydrocarbon ring, where the above groups (1) to (3) of Ar are optionally substituted with 1 to 5 groups selected from the group consisting of: (i) a halogen atom, (ii) nitro, (iii) cyano, (iv) C1 to C6 alkyl optionally substituted with 1 to 3 halogen atoms, (v) C2 to C6 alkenyl optionally substituted with 1 to 3 halogen atoms, (vi) C2 to C6 alkynyl optionally substituted with 1 to 3 halogen atoms, (vii) C3 to C6 cycloalkyl, (viii) hydroxyl, (ix) C1 to C6 alkoxy optionally substituted with 1 to 3 groups selected from the group consisting of a halogen atom, mono- or di-C1 to C6 alkylamino, C1 to C6 alkoxy, mono- or di-C1 to C6 alkylcarbamoyl, mono- or di-C7 to C16 aralkylcarbamoyl, mono- or di-C1 to C10 heteroaryl-C1 to C6 alkylcarbamoyl, carboxyl, and C1 to C6 alkoxycarbonyl, or substituted with 1 to 13 deuterium atom, (x) C1 to C5 alkylenedioxy, (xi) C1 to C6 alkylthio optionally substituted with 1 to 3 groups selected from the group consisting of a halogen atom, mono- or di-C1 to C6 alkylamino, C1 to C6 alkoxy, mono- or di-C1 to C6 alkylcarbamoyl, mono- or di-C7 to C16 aralkylcarbamoyl, mono- or di-C1 to C10 heteroaryl-C1 to C6 alkylcarbamoyl, carboxyl, and C1 to C6 alkoxycarbonyl, or substituted with 1 to 13 deuterium atom, (xii) amino, (xiii) mono-C1 to C6 alkylamino, (xiv) di-C1 to C6 alkylamino, (xv) 5- to 6-membered cyclic amino, (xvi) C1 to C6 alkylcarbonyl, (xvii) carboxyl, (xviii) C1 to C6 alkoxycarbonyl, (xix) carbamoyl, (xx) thiocarbamoyl, (xxi) mono-C1 to C6 alkylcarbamoyl, (xxii) di-C1 to C6 alkylcarbamoyl, (xxiii) 5- to 6-membered cyclic aminocarbonyl, (xxiv) sulfo, (xxv) C1 to C6 alkylsulfonyl (xxvi) C1 to C6 alkoxycarbonylamino, (xxvii) C1 to C6 alkylcarbonylamino, (xxviii) mono- or di-C1 to C6 alkylaminocarbonylamino, (xxix) aminosulfonyl, and (xxx) mono- or di-C1 to C6 alkylaminosulfonyl, or substituted with 1 to 9 deuterium atoms, X indicates (1) a connecting bond, (2) linear or branched C1 to C6 alkylene optionally substituted with 1 to 12 deuterium atoms, (3) an oxygen atom, (4) NR3, where R3 indicates a hydrogen atom or a C1 to C6 alkyl group, or (5) —S(O)m—, where m indicates an integer of 0 to 2, Z indicates (1) a connecting bond or (2) CR4R5 where R4 and R5 are, independently, (A) a hydrogen atom, (B) a deuterium atom, (C) C1 to C6 alkyl optionally substituted with 1 to 5 groups selected from the group consisting of (i) carboxyl, (ii) C1 to C6 alkoxycarbonyl, (iii) phenyl, (iv) hydroxyl, (v) C1 to C6 alkoxy, (vi) halogen atom, and (vii) C3 to C6 cycloalkyl, or substituted with 1 to 13 deuterium atoms, (D) C3 to C6 cycloalkyl optionally substituted with 1 to 5 groups selected from the group consisting of (i) a halogen atom and (ii) an alkyl group optionally substituted with 1 to 3 halogen atoms or optionally substituted, with 1 to 11 deuterium atoms, (E) COOR6, where R6 indicates a hydrogen atom or C1 to C6 alkyl, or (F) CONR7R8, where R7 and R8 are, independently, (a) hydrogen atom, (b) C1 to C6 alkyl optionally substituted with 1 to 3 groups selected from the group consisting of (i) a halogen atom, (ii) C3 to C6 cycloalkyl, (iii) carboxyl, (iv) C1 to C6 alkoxycarbonyl, (v) C1 to C6 alkylcarbonyl, (vi) carbamoyl, (vii) mono-C1 to C6 alkylcarbamoyl, (viii) di-C1 to C6 alkylcarbamoyl, (ix) C6 to C12 aryl, and (x) C1 to C10 heteroaryl, (c) C6 to C14 aromatic hydrocarbon group, (d) a 5- to 8-membered aromatic heterocyclic group having 1 to 4 hetero atoms selected from the group consisting of a nitrogen atom, sulfur atom, and oxygen atom, in place of a carbon atom, or (e) a bicyclic or tricyclic aromatic group formed by condensation of the above aromatic heterocyclic, group and a C6 to C14 aromatic hydrocarbon ring, where each of the groups (c) to (e) is optionally substituted with 1 to 5 groups selected from the group consisting of (i) a halogen atom, (ii) nitro, (iii) cyano, (iv) C1 to C6 alkyl optionally substituted with 1 to 3 halogen atoms, (v) C2 to C6 alkenyl optionally substituted with 1 to 3 halogen atoms, (vi) C2 to C6 alkynyl optionally substituted with 1 to 3 halogen atoms, (vii) C3 to C6 cycloalkyl, (viii) hydroxyl, (ix) C1 to C6 alkoxy optionally substituted with 1 to 3 halogen atoms, (x) C1 to C5 alkylenedioxy, (xi) C1 to C6 alkylthio optionally substituted with 1 to 3 halogen atoms, (xii) amino, (xiii) mono-C1 to C6 alkylamino, (xiv) di-C1 to C6 alkylamino, (xv) 5- to 6-membered cyclic amino, (xvi) C1 to C6 alkylcarbonyl, (xvii) carboxyl, (xviii) C1 to C6 alkoxycarbonyl, (xix) carbamoyl, (xx) thiocarbamoyl, (xxi) mono-C1 to C6 alkylcarbamoyl, (xxii) di-C1 to C6 alkylcarbamoyl, (xxiii) C6 to C10 arylcarbamoyl, (xxiv) C1 to C10 heteroarylcarbamoyl, (xxv) sulfo, (xxvi) C1 to C6 alkylsulfonyl, (xxvii) aminosulfonyl, and (xxviii) mono- or di-C1 to C6 alkylaminosulfonylamino, or substituted with 1 to 9 deuterium atoms, W indicates (1) a hydrogen atom, (2) a C6 to C14 aromatic hydrocarbon group, (3) a 5- to 8-membered aromatic heterocyclic group having 1 to 4 hetero atoms selected from a nitrogen atom, a sulfur atom, and an oxygen atom, in place of a carbon atom, (4) a bicyclic, or tricyclic aromatic group formed by condensation of the above aromatic heterocyclic group and a C6 to C14 aromatic hydrocarbon ring, or a deuterium atom, where, each of the groups (2) to (4) of the above W is optionally substituted with 1 to 5 groups selected from the group consisting of (i) a halogen atom, (ii) nitro, (iii) cyano, (iv) C1 to C6 alkyl optionally substituted with 1 to 3 groups selected from the group consisting of a halogen atom, amino, C1 to C6 alkoxycarbonyl, C1 to C6 alkoxycarbonylamino, and carboxyl, (v) C2 to C6 alkenyl optionally substituted with 1 to 3 halogen atoms, (vi) C2 to C6 alkynyl optionally substituted with 1 to 3 halogen atoms, (vii) C3 to C6 cycloalkyl, (viii) hydroxyl, (ix) C1 to C6 alkoxy optionally substituted with 1 to 3 groups selected from the group consisting of a halogen atom, hydroxyl, C1 to C6 alkoxy, amino and mono- or di-C1 to C6 alkylamino, (x) C1 to C5 alkylenedioxy, (xi) C1 to C6 alkylthio optionally substituted with 1 to 3 groups selected from the group consisting of a halogen atom, hydroxyl, C1 to C6 alkoxy, amino, and mono- or di-C1 to C6 alkylamino, (xii) amino, (xiii) mono-C1 to C6 alkylamino, (xiv) di-C1 to C6 alkylamino, (xv) 5- to 6-membered cyclic amino, (xvi) C1 to C6 alkyl-carbonyl, (xvii) carboxyl, (xviii) C1 to C6 alkoxycarbonyl optionally substituted with a halogen atom, (xix) C7 to C16 aralkyloxycarbonyl optionally substituted with a halogen atom, (xx) carbamoyl, (xxi) mono-C1 to C6 alkylcarbamoyl optionally substituted with 1 to 3 groups which are selected from the group consisting of a halogen atom, hydroxyl, carboxyl, C1 to C6 alkoxy, amino, and mono- or di-C1 to C6 alkylamino, (xxii) di-C1 to C6 alkylcarbamoyl optionally substituted with hydroxyl, (xxiii) 5- to 6-membered cyclic aminocarbonyl optionally substituted with C1 to C6 alkoxycarbonyl, (xxiv) C6 to C10 arylcarbamoyl, (xxv) C1 to C10 heteroarylcarbamoyl, (xxvi) C7 to C16 aralkylcarbamoyl, (xxvii) C1 to C10 heteroaryl-C1 to C6 alkylcarbamoyl, (xxviii) N—C1 to C6 alkyl-N—C6 to C12 arylcarbamoyl, (xxix) C3 to C6 cycloalkylcarbamoyl, (xxx) sulfo, (xxxi) C1 to C6 alkylsulfonyl, (xxxii) C1 to C6 alkylsulfonylamino, (xxxiii) C6 to C12 arylsulfonylamino optionally substituted with C1 to C6 alkyl, (xxxiv) C1 to C10 heteroarylsulfonylamino, (xxxv) C1 to C6 alkoxycarbonylamino, (xxxvi) C1 to C6 alkylcarbonylamino, (xxxvii) mono- or di-C1 to C6 alkylaminocarbonylamino, (xxxviii) C6 to C12 aryl, (xxxix) C1 to C10 heteroaryl, (xl) C6 to C10 aryloxy, (xli) C1 to C10 heteroaryloxy, (xlii) C7 to C16 arakyloxy, (xliii) C1 to C10 heteroaryl-C1 to C6 alkyloxy, (xliv) aminosulfonyl, (xlv) mono- or di-C1 to C6 alkylaminosulfonyl, (xlvi) C7 to C16 aralkyloxycarbamoyl, and (xlvii) C1 to C10 heteroaryl-C1 to C6 alkyloxycarbamoyl, or substituted with 1 to 9 deuterium atoms, R1 indicates (1) a hydrogen atom, (2) C1 to C6 alkyl optionally substituted with 1 to 3 of (i) a halogen atom or (ii) C3 to C6 cycloalkyl or substituted with (iii) 1 to 13 deuterium atoms, (3) C2 to C6 alkenyl optionally substituted with 1 to 3 of (i) a halogen atom or (ii) C3 to C6 cycloalkyl or substituted with (iii) 1 to 11 deuterium atoms, (4) C2 to C6 alkynyl optionally substituted with 1 to 3 of (i) a halogen atom or (ii) C3 to C6 cycloalkyl, or substituted with (iii) 1 to 9 deuterium atoms, or (5) C3 to C6 cycloalkyl optionally substituted with 1 to 3 of (i) a halogen atom or (ii) C3 to C6 cycloalkyl, or substituted with (iii) 1 to 11 deuterium atoms, R2 indicates (1) OR9 or (2) NR10R11 where, R9, R10, and R11 independently indicate (A) a hydrogen atom, (B) C1 to C6 alkyl, (C) C2 to C6 alkenyl, (D) C3 to C6 alkynyl, (E) C3 to C6 cycloalkyl (F) C6 to C14 aromatic hydrocarbon group, (G) a 5- to 8-membered aromatic heterocyclic group having 1 to 4 hetero atoms selected from the group consisting of a nitrogen atom, sulfur atom, and oxygen atom, in place of a carbon atom, or (H) a bicyclic or tricyclic aromatic group formed by condensation of the above aromatic heterocyclic group and a C6 to C14 aromatic hydrocarbon ring, where each of the groups of the above (B) to (E) is optionally substituted with 1 to 3 groups selected from the group consisting of (i) a halogen atom, (ii) C3 to C6 cycloalkyl, (iii) hydroxyl, (iv) C1 to C6 alkoxy optionally substituted with 1 to 3 halogen atoms, (v) amino, (vi) mono-C1 to C6 alkylamino, (vii) di-C1 to C6 alkylamino, (viii) 5 to 6-membered cyclic amino, (ix) carboxyl, (x) C1 to C6 alkoxycarbonyl, (xi) C1 to C6 alkylcarbonyl, (xii) carbamoyl, (xiii) mono-C1 to C6 alkylcarbamoyl, (xiv) di-C1 to C6 alkylcarbamoyl, (xv) C6 to C12 aryl, and (xvi) C1 to C10 heteroaryl, or substituted with 1 to 13 deuterium atoms, further, each of the groups of the above (F) to (H) are optionally substituted with 1 to 5 groups which are selected from the group consisting of (i) a halogen atom, (ii) nitro, (iii) cyano, (iv) C1 to C6 alkyl optionally substituted with 1 to 3 halogen atoms, (v) C3 to C6 cycloalkyl optionally substituted with 1 to 3 halogen atoms, (vi) hydroxyl, (vii) C1 to C6 alkoxy optionally substituted with 1 to 3 halogen atoms, (viii) amino, (ix) mono-C1 to C6 alkylamino, (x) di-C1 to C6 alkylamino, (xi) 5- to 6-membered cyclic amino, (xii) C1 to C6 alkylcarbonyl, (xiii) carboxyl, (xiv) C1 to C6 alkoxycarbonyl, (xv) carbamoyl, (xvi) mono-C1 to C6 alkylcarbamoyl, (xvii) di-C1 to C6 alkylcarbamoyl, (xviii) C1 to C6 alkylsulfonyl, (xix) aminosulfonyl, and (xx) mono- or di-C1 to C6 alkylaminosulfonyl, or substituted with 1 to 9 deuterium atoms, or R1 and R2 may form 5- or 6-member heterocyclic ring together with the atoms they are bonded with, where the above 5- or 6-member heterocyclic ring is optionally substituted with 1 to 3 groups selected from the group consisting of (A) a halogen atom, (B) oxo, (C) hydroxyl (D) C1 to C6 alkyl, (E) C2 to C6 alkenyl, (F) C2 to C6 alkynyl, (G) C3 to C6 cycloalkyl (H) C6 to C14 aromatic hydrocarbon group, (I) 5- to 8-membered aromatic heterocyclic group having 1 to 4 hetero atoms selected from the group consisting of a nitrogen atom, sulfur atom, and oxygen atom, in place of a carbon atom, and (J) a bicyclic or tricyclic aromatic group formed by condensation of the above aromatic heterocyclic group and a C6 to C14 aromatic hydrocarbon ring, or substituted with (K) 1 to 6 deuterium atoms, where each of the groups of the above (D) to (G) is optionally substituted with 1 to 3 groups selected from the group consisting of (i) a halogen atom, (ii) C3 to C6 cycloalkyl, (iii) hydroxyl, (iv) C1 to C6 alkoxy optionally substituted with 1 to 3 halogen atoms, (v) amino, (vi) mono-C1 to C6 alkylamino, (vii) di-C1 to C6 alkylamino, (viii) 5- to 6-membered cyclic amino, (ix) carboxyl, (x) C1 to C6 alkoxycarbonyl, (xi) C1 to C6 alkyl-carbonyl, (xii) carbamoyl, (xiii) mono-C1 to C6 alkylcarbamoyl, (xiv) di-C1 to C6 alkylcarbamoyl, (xv) C6 to C12 aryl and (xvi) C1 to C10 heteroaryl, or substituted with 1 to 13 deuterium atoms, each of the groups of the above (H) to (J) is optionally substituted with 1 to 5 groups which are selected from the group consisting, of (i) a halogen atom, (ii) nitro, (iii) cyano, (iv) C1 to C6 alkyl optionally substituted with 1 to 3 halogen atoms, (v) C3 to C6 cycloalkyl optionally substituted with 1 to 3 halogen atoms, (vi) hydroxyl, (vii) C1 to C6 alkoxy optionally substituted with 1 to 3 halogen atoms, (viii) amino, (ix) mono-C1 to C6 alkylamino, (x) di-C1 to C6 alkylamino, (xi) 5- to 6-membered cyclic amino, (xii) C1 to C6 alkylcarbonyl, (xiii) carboxyl, (xiv) C1 to C6 alkoxycarbonyl, (xv) carbamoyl, (xvi) mono-C1 to C6 alkylcarbamoyl, (xvii) di-C1 to C6 alkylcarbamoyl, (xviii) C1 to C6 alkylsulfonyl, (xix) aminosulfonyl, and (xx) mono- or di-C1 to C6 alkylaminosulfonyl, or substituted with 1 to 9 deuterium atoms. |
