Indolyl or indolinyl hydroxamate compounds

摘要

Indolyl or indolinyl compounds of formula (I):;
wherein bond, n, R1, R2, R3, R4, R5, and R6, are defined herein. Also disclosed is a method for treating cancer with these compounds.

主权项

1. A compound of formula (I):wherein
is a single bond or a double bond; n is 0, 1, or 2; R1 is SO2Ra, in which Ra is alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl; R2 is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, halo, cyano, nitro, ORb, SRb, S(O)Rb, NHC(O)—CH═CH—C(O)Rb, NHC(O)—CH═CH—C(O)NRcRd, SO2NRcRd, OC(O)Rb, C(O)NRcRd, NRcRd, NHC(O)Rb, NHC(O)NRcRd, or NHC(S)Rc, in which each of Rb, Rc, and Rd, independently, is H, hydroxy, alkoxy, aryloxy, heteroaryloxy, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl; each of R3, R4, R5, and R6, independently is, H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, halo, cyano, nitro, ORb, SRb, S(O)Rb, CH═CH—C(O)NRcRd, NHC(O)—CH═CH—C(O)Rb, NHC(O)—CH═CH—C(O)NRcRd, SO2NRcRd, OC(O)Rb, C(O)NRcRd, NRcRd, NHC(O)Rb, NHC(O)NRcRd, or NHC(S)Rc, in which each of Rb, Rc, and Rd, independently, is H, hydroxy, alkoxy, aryloxy, heteroaryloxy, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl; and when R1 is SO2Ra, R2 is NHC(O)—CH═CH—C(O)Rb or NHC(O)—CH═CH—C(O)NRcRd; at least one of R3, R5, and R6 is CH═CH—C(O)NRcRd, NHC(O)—CH═CH—C(O)Rb, or NHC(O)—CH═CH—C(O)NRcRd; or R4 is C(O)NRcRd, CH═CH—C(O)NRcRd, NHC(O)—CH═CH—C(O)Rb, or NHC(O)—CH═CH—C(O)NRcRd.