Improved method for preparing dipeptidyl peptidase-iv inhibitor and intermediate

摘要

608028 Disclosed herein is an improved method for preparing a dipeptidyl peptidase-IV inhibitor and intermediate thereof which is able to reduce preparation costs by using low cost reagents on reaction and is able to be used in mass production by improving yield. In one embodiment an intermediate (2) is prepared by a method comprises steps a) reacting an epoxide compound (5) with a Grignard reagent, b) reacting the halogen product (6) with sodium azide, c) reacting the azide product (7) with triphenylphosphine, d) reacting the aziridine product (8) with a cyanogen-based reagent, e) and hydrolysis of the cyanide product (9) with a base.