发明名称 |
NEW BICYCLIC DIHYDROISOQUINOLINE-1-ONE DERIVATIVES |
摘要 |
<p>The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, A1, A2, A3, A4, A5 and n are as described herein, compositions including the compounds and methods of using the compounds. The compounds are useful, for example, as aldosterone synthase (CYP11B2 or CYP11B1) inhibitors for the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome.</p> |
申请公布号 |
SG11201402199Q(A) |
申请公布日期 |
2014.09.26 |
申请号 |
SG11201402199Q |
申请日期 |
2012.11.27 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
AEBI, JOHANNES;AMREIN, KURT;CHEN, WENMING;HORNSPERGER, BENOIT;KUHN, BERND;LIU, YONGFU;MAERKI, HANS P.;MAYWEG, ALEXANDER V.;MOHR, PETER;TAN, XUEFEI;WANG, ZHANGUO;ZHOU, MINGWEI |
分类号 |
C07D217/22;A61K31/4375;A61K31/4725;A61P9/12;C07D401/04;C07D401/14;C07D405/14;C07D413/14;C07D417/14;C07D471/04;C07D491/107;C07D491/113 |
主分类号 |
C07D217/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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