MONOCLONAL ANTIBODIES AGAINST ANTITHROMBIN BETA COMPLEXED WITH HEPARIN
摘要
This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin &bgr; complexed with heparin and/or heparin-like structure (&Agr;&Tgr;&bgr;&EEgr;). These &Agr;&Tgr;&bgr;&EEgr; binding proteins can block the anti-coagulant activity of &Agr;&Tgr;&bgr; to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies.