USE OF TRANSLATIONAL PROFILING TO IDENTIFY TARGET MOLECULES FOR THERAPEUTIC TREATMENT

摘要

The present invention provides methods of identifying an agent or drug candidate molecule, validating a target, and identifying normalizing therapeutics that modulates translation, such as in an oncogenic signaling pathway, in a biological sample as determined by translational profiling of one or more genes in the biological sample. The present invention also provides diagnostic and therapeutic methods using the translational profiling methods described herein.

主权项

1. A method for identifying a candidate therapeutic for treating a disease, the method comprising:
(a) determining a first translational profile for a plurality of genes for a disease sample that has been contacted with a candidate agent; (b) determining a second translational profile for a plurality of genes for a disease sample that has not been contacted with the agent; and (c) identifying the agent as a candidate therapeutic for treating the disease when one or more genes are differentially translated in the first translation profile as compared to the second translation profile and when the differential translation results in a biological benefit.