METHODS AND COMPOSITIONS FOR THE TREATMENT OF METABOLIC SYNDROME, OBSTRUCTIVE RESPIRATORY DISORDERS, CANCER AND RELATED DISEASES

摘要

Compositions comprising IGFBP-3 receptor agonists and methods for the treatment of metabolic syndrome, obstructive respiratory disorders, obstructive or inflammatory respiratory disease, cancers and related diseases with IGFBP-3 receptor agonists are presented. A method for interfering with the activity of nuclear factor-kappaB (NF-KB) in a cell, comprising: providing to a cell an effective amount of a composition comprising an IGFBP-3 receptor agonist; and interfering with the activity of NF-KB in the cell is included.

主权项

1. A method for interfering with the activity of nuclear factor-kappaB (NF-κB) in a cell, comprising:
providing to a cell an effective amount of a composition comprising an IGFBP-3 receptor agonist, wherein the IGFBP-3 receptor agonist comprises at least a portion of IGFBP-3, an antibody or a fragment thereof capable of binding at least a portion of an IGFBP-3 receptor, a vector capable of expressing at least a portion of IGFBP-3, or an adenovirus expressing at least a portion of IGFBP-3.