发明名称 ANTI-CD19 ANTIBODIES WITH REDUCED IMMUNOGENICITY
摘要 Anti-CD19 B4 antibodies with modified variable regions are disclosed. The modified anti-CD19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regions of the heavy chain variable region or light chain variable region, thereby to reduce a T-cell response.
申请公布号 US2014288288(A1) 申请公布日期 2014.09.25
申请号 US201414222517 申请日期 2014.03.21
申请人 Merck Patent GmbH 发明人 Super Michael;Davis Jonathan;Stein Pascal André
分类号 C07K16/28 主分类号 C07K16/28
代理机构 代理人
主权项
地址 Darmstadt DE