PROCESS FOR THE PREPARATION OF RANDOM POLYPEPTIDES AND EMPLOYING CIRCULAR DICHROISM AS A GUIDANCE TOOL FOR THE MANUFACTURE OF GLATIRAMER ACETATE

摘要

The present invention discloses novel process for the preparation of mixture of polypeptides comprising L-Glutamaic acid, L-Alanine, L-Tyrosine, and L-Lysine. by employing circular dichroism as a guidance tool.

主权项

1. A process for preparing a polypeptide containing L-Glutamate, L-Alanine, L-Tyrosine, and L-Lysine employing circular dichroism as a guidance tool, the method comprising;
i. polymerizing an N-carboxyanhydride (NCA) derivative of a protected L-Glutamate, L-Alanine, optionally protected L-Tyrosine, and protected L-Lysine, ii. optionally treating with an acidic resin in a solvent, iii. treating with base in solvent, iv. adjusting the pH with acetic acid, and v. isolating glatiramer acetate.