发明名称 |
ANTIBODY DRUG CONJUGATE (ADC) PURIFICATION |
摘要 |
<p>The invention provides methods for obtaining compositions having antibody drug conjugates (ADCs) with specified drug to antibody ratios (DARs). Included in the invention is a method for purifying an ADC mixture having ADCs with a drug loaded species of 6 or more by contacting the mixture with a hydrophobic resin such that a composition comprising less than 15% of the 6 or more drug loaded species is obtained. The invention also provides a composition wherein 70% or more of the ADCs present have a drug loaded species of 4 or less, wherein the ADC comprises an anti-EGFR antibody and an auristatin.</p> |
申请公布号 |
CA2906022(A1) |
申请公布日期 |
2014.09.25 |
申请号 |
CA20142906022 |
申请日期 |
2014.03.14 |
申请人 |
ABBVIE INC. |
发明人 |
LEANNA, MARVIN ROBERT;BECKER, CALVIN LAWRENCE |
分类号 |
A61K47/48;A61P35/00 |
主分类号 |
A61K47/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|