发明名称 |
TRANSDERMAL DOSAGE FORM FOR LOW-MELTING POINT ACTIVE AGENT |
摘要 |
<p>A drug-containing patch allows transdermal administration of a drug. The patch features a hydrophobic reservoir containing the drug, where the reservoir has a first surface and a second surface. A drug-impermeable backing overlies the first surface of the reservoir. A release sheet may overlie the second surface of the reservoir. The hydrophobic reservoir contains a drug and a hydrophobic matrix, where the hydrophobic matrix includes a hydrophobic filler in an amount which is effective to adsorb said drug; and a mixture of polyisobutylene and mineral oil. The hydrophobic matrix may contain hydrophobic colloidal silica as the hydrophobic filler. The hydrophobic reservoir layer may serve as a skin-contacting adhesive layer. Alternatively, a release-controlling adhesive layer may serve as the skin-contacting adhesive layer. The release-controlling adhesive layer may contain hydrophobic colloidal silica and a mixture of polyisobutylene and mineral oil.</p> |
申请公布号 |
WO2014105575(A4) |
申请公布日期 |
2014.09.25 |
申请号 |
WO2013US76177 |
申请日期 |
2013.12.18 |
申请人 |
MYLAN, INC. |
发明人 |
SIVARAMAN, ARUNPRASAD;SIMMONS, TYLER D.;FIELDSON, GREGORY T.;SORENSON, ADAM;CORTOPASSI, JEFFREY E. |
分类号 |
A61K9/70 |
主分类号 |
A61K9/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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