Biomarkers for amyotrophic lateral sclerosis and methods using the same

摘要

The present invention provides various biomarkers of amyotrophic lateral sclerosis (ALS). The present invention also provides various methods of using the biomarkers, including methods for diagnosis of ALS, methods of determining predisposition to ALS, methods of monitoring progression/regression of ALS, methods of assessing efficacy of compositions for treating ALS, methods of screening compositions for activity in modulating biomarkers of ALS, methods of treating ALS, as well as other methods based on biomarkers of ALS.

主权项

1. A method of aiding in diagnosing whether a subject has amyotrophic lateral sclerosis (ALS), comprising:
analyzing a cerebral spinal fluid, blood, or blood plasma sample from a subject to determine the levels of a plurality of biomarkers for amyotrophic lateral sclerosis in the sample, wherein the plurality of biomarkers comprise creatine-creatinine and citrulline and wherein the analysis method for the sample is mass spectrometry, and comparing the levels of the plurality of biomarkers in the sample to ALS-positive and/or ALS-negative reference levels of the plurality of biomarkers in order to aid in diagnosing whether the subject has amyotrophic lateral sclerosis.