发明名称 |
Solid forms of an antiviral compound |
摘要 |
Crystalline solid forms and the amorphous form of the anti-HCV compound 5-(3,3-dimethylbutyn-1-yl)-3-[(cis-4-hydroxy-4-{[(3S)-tetrahydrofuran-3-yloxy]methyl}cyclohexyl){[(1R)-4-methylcyclohex-3-en-1-yl]carbonyl}amino]thiophene-2-carboxylic acid (Compound I) were prepared and characterized in the solid state:;
Also provided are processes of manufacture and methods of using the crystalline forms. |
申请公布号 |
US8841340(B2) |
申请公布日期 |
2014.09.23 |
申请号 |
US201313800991 |
申请日期 |
2013.03.13 |
申请人 |
Gilead Sciences, Inc. |
发明人 |
Hashash Ahmad;Wolckenhauer Scott;Shi Bing |
分类号 |
A01N43/06;A61K31/38;C07D409/00 |
主分类号 |
A01N43/06 |
代理机构 |
Kilpatrick, Townsend & Stockton LLP |
代理人 |
Kilpatrick, Townsend & Stockton LLP |
主权项 |
1. Crystalline 5-(3,3-dimethylbutyn-1-yl)-3-[(cis-4-hydroxy-4-{[(3S)-tetrahydrofuran-3-yloxy]methyl}cyclohexyl){[(1R)-4-methylcyclohex-3-en-1-yl]carbonyl}amino]thiophene-2-carboxylic acid hydrate (Compound I Form I) characterized by an X-ray powder diffractogram comprising at least three of the following peaks: 4.0, 7.3, 8.1, 17.9, or 21.8° 2θ±0.2° 2θ, as determined on a diffractometer using Cu-Kα radiation. |
地址 |
Foster City CA US |