Temperature-adjusted analyte determination for biosensor systems

摘要

A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations and output signals at a reference temperature may be used to determine analyte concentrations from output signals at a sample temperature.

主权项

1. A method for determining an analyte concentration in a sample of a biological fluid, comprising:
determining a sample temperature; generating an output signal in response to a redox reaction of an analyte in the sample at a sample temperature; selecting a previously determined correlation between output signals and analyte concentrations for a reference temperature; selecting a previously developed normalized temperature function, the development of the normalized temperature function comprising:
determining a correlation between output signals and analyte concentrations for at least one other temperature; andnormalizing the correlation at the at least one other temperature to the correlation of the reference temperature; adjusting the previously determined correlation with the previously developed normalized temperature function, to obtain a temperature-adjusted correlation; and calculating an analyte concentration from the output signal and the temperature-adjusted correlation.