Systems and methods for replacing signal artifacts in a glucose sensor data stream

摘要

Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.

主权项

1. A method for processing data from a glucose sensor, the method comprising:
applying a voltage to a working electrode of an electrochemical glucose sensor configured for invasive and/or minimally invasive subcutaneous implantation, invasive and/or minimally invasive transdermal implantation, or invasive and/or minimally invasive intravascular implantation, wherein the electrochemical glucose sensor is configured for measurement of a glucose concentration, wherein applying a voltage comprises at least one process selected from the group consisting of switching a voltage applied to the electrochemical sensor, cycling a voltage applied to the electrochemical sensor, and pulsing a voltage applied to the electrochemical sensor; and detecting a signal artifact based on a signal response of the electrochemical glucose sensor to the switching, cycling, or pulsing of the applied voltage, wherein the signal artifact is associated with at least one condition selected from the group consisting of ischemia, a pH change, a temperature change, a change in available electrode surface area, and an interfering species.