发明名称 |
LIPID HYDROLYSIS THERAPY FOR ATHEROSCLEROSIS AND RELATED DISEASES |
摘要 |
The present invention comprises a method to diminish and/or eliminate atherosclerotic plaques, in mammals, through direct and indirect treatment of these plaques, in situ, using suitable substances which are capable of lipid removal, primarily through hydrolysis, either by a catalytic or stoichiometric process, wherein the substance targets receptors in and/or on the cell which lead to uptake into the lysosome. Such substances used to diminish and/or eliminate atherosclerotic plaques are generally comprised of lipid hydrolyzing proteins and/or polypeptides. |
申请公布号 |
CA2398995(C) |
申请公布日期 |
2014.09.23 |
申请号 |
CA20012398995 |
申请日期 |
2001.02.02 |
申请人 |
CHILDREN'S HOSPITAL RESEARCH FOUNDATION |
发明人 |
GRABOWSKI, GREGORY A.;DU, HONG |
分类号 |
A61K38/46;C12N15/09;A61K35/76;A61K38/00;A61K48/00;A61P3/06;A61P9/10;C12N9/20 |
主分类号 |
A61K38/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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